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Resomelagon acetate (AP1189 acetate) is a potent, orally active melanocortin receptor (MR) agonist, specifically targeting MC1 and MC3. It induces ERK1/2 phosphorylation and Ca2+ mobilization, exhibiting anti-inflammatory activity. This compound is applicable for research in obesity and chronic inflammation.
Potent, orally active melanocortin receptor agonist
Specifically targets MC1 and MC3
Induces ERK1/2 phosphorylation and Ca2+ mobilization
Exhibits anti-inflammatory activity
Inhibits TNF-α release and efferocytosis
Promotes resolution of acute inflammation
Reduces arthritis in mice
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nor-NOHA (acetate) (CAS 1140844-63-8) is a potent reversible inhibitor of rat liver arginase (Ki 0 5 M) By competitively inhibiting arginase nor-NOHA modulates the cellular balance between the L-arginine-dependent pathways of nitric oxide synthase (NOS) and arginase affecting nitric oxide production and urea cycle metabolism In vitro studies have shown that nor-NOHA suppresses proliferation migration and invasion of HepG2 hepatocellular carcinoma cells induces apoptosis and alters expression of Arg1 MMP-2 P53 and ECD In vivo nor-NOHA improves endothelial function in rat models of inflammation by enhancing NOS activity increasing EDHF and reducing superoxide anion production This compound is widely used to investigate arginase-related mechanisms in cellular and vascular biology
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RI-AG03 acetate is the acetate of RI-AG03. It is an orally active and BBB-penetrable Tau aggregation peptide inhibitor. It inhibits Tau aggregation and improves associated neurodegeneration and behavioral phenotypes in both in vivo and in vitro models, making it suitable for studying tauopathies such as Alzheimer's disease.
Orally active and BBB-penetrable Tau aggregation peptide inhibitor
Inhibits Tau aggregation
Improves associated neurodegeneration and behavioral phenotypes in both in vivo and in vitro models
Suitable for studying tauopathies such as Alzheimer's disease
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More